- Accidental Innuendo: At one point, in discussing Bernard, Lenina and Fanny comment that he is "so small" (emphasis in original). Of course, in context, it is clear that they are discussing his short stature; however, to some readers, it can appear that they are talking about a different kind of size.
- Darkness-Induced Audience Apathy: The sheer soul-crushing hopelessness of the story combined with the utter depravity of the Crapsack World it portrays has been known to cause severe bouts of depression in readers. In fact, the novel was chastised by critics for precisely this reason upon its initial publication in 1932.
- Hilarious in Hindsight:
- The worship of Henry Ford looks even sillier given the direction of his namesake company and the U.S. car industry as a whole.
- The description of in-vitro fertilization years before the world's first test-tube baby was born.
- Moral Event Horizon: The painful conditioning of Delta babies against books and flowers.
- Squick: In the casually promiscuous society in which the book takes place, it is considered healthy - even endearing - for young children to sexually experiment with each other. There is also a memorable passage pointing out the more Freudian aspects of breastfeeding, and the descriptions of John's mother.
- Values Resonance: One of the newer printings says this on the back cover.
- What Do You Mean, It's Not Didactic?: The novel might have been written as a Take That! against the excesses of 1920s hedonism.
- The Woobie: Poor, poor John "The Savage". As if growing up bullied and ostracized by everyone was bad enough, he ends up despising the very world he thought would be his one salvation. And after being ostracized there too and paraded around like a circus animal, he chooses exile. After the curiosity seekers chase him even there, and after betraying his beliefs in a drug-induced stupor, he is finally Driven to Suicide.
- Arc Fatigue: The Enchanted Express arc went on for several hundred thousand words and over a year - and even the author eventually admitted that "the saga of the Excess Express" dragged on for longer than expected.
- Ending Fatigue: It's 2.4 million words long, with the end nowhere in sight.
- Fake Longevity: A curious, non-video game example. Yes, it's almost two and a half million words long, but a considerable amount of it can be skipped without any major loss of plot details. Transformation scenes abound, the overly long gags go on long enough that it makes Tarantulas sympathetic when he gets sick of hearing them, and several plots barely qualify for even tangential relevance. Chapter 66 shows this - it's 76,000 words of Nihilators dying, but with scarcely a mention of Team Aurabolt or Oblivion's Shadow.
- Hilarious in Hindsight: All of the events in Pokémon Mystery Dungeon occuring in one continuity instead of Alternate Universe? A crazy idea that only occurs in fanfics, I say!
- Kudzu Plot: To almost ludicrous levels. The story starts with Team Aurabolt and the quest for the seven Star Badges. Meanwhile, fifty chapters down the line, we see Caserin the Luvdisc, Mack Salmon, Bruce the Oztralian Sharpedo and some other characters of Nominal Importance searching for the Aqua-Monica.
- Moral Event Horizon: Well, where do you start for the Nihilator high command...