Yozora's mean streak and selfishness are obvious, but almost all of her bile seems reserved for Sena and Maria, the arrogant RichAlpha Bitch and Insufferable GeniusBratty Half-Pint. As the series goes on, she starts getting the hints of when she goes too far in her Break the Haughty hobby, as when she pushes Sena too far until she passionately admits her devotion to Eroge in such a way that even Rika is shocked. Yozora honestly apologizes.
Some fans theorize that Yukimura's obsession with being "a true Japanese man" may indicate being a female-to-male Transgender.
Harsher in Hindsight: Stella gave Kodaka a condom! How hilarious! Then in the Connect extras it's revealed that Stella is the end result of a teenage pregnancy from a fling Pegasus had in high school and one realises that she might actually have been genuinely concerned that her little half-sister could suffer a similar fate.
Sena and Yozora are both unpleasant people who don't give much consideration to others, and can often be outright intentionally cruel, malicious, or vindictive. But you can't help but feel really sorry for them every time they accidentally say or do something that highlights that they're just really lonely people who want to make friends but don't know how. Well, that and they tend to suffer amusingly for their own behavior.
Yozora's woobie status seems to have kicked into high gear as of the end of Volume 9, as the reasons for her dislike of romance and same-sex friendships are laid bare (her mother's best friend betrayed her by having an affair with her father), and is shown to have a dysfunctional relationship with her sister Hinata as the two took opposite sides in a bitter divorce. Needless to say, Sena's confession and Kodaka hiding out with the Student Council in Volume 8 didn't help, nor did her overhearing Kodaka and Rika's conversation at the end of the volume. Oh and said mother has become such a bitter wreck that she once flipped out and stabbed her.
Les Yay: There's something more to Yozora and Sena's relationship than their frequent squabbles would indicate. On Yozora's side, she believes nicknames are only for friends, even if it was as insulting as Sena's "Meat". On Sena's side, she confessed to Kodaka that she's secretly happy with her nickname because she has never been given one before. Then comes actual interaction: during the Beach Episode Sena was apparently enjoying Yozora rubbing her back with suntan with her feet, and also commented that Yozora, post-haircut, looks ridiculously handsomein a male school uniform. Not to mention Sena plastering her bedroom ceiling with pictures of Yozura and the shots of her smelling Yozura's wig with her hand between her legs!
One True Threesome: People who aren't just satisfied with Kodaka/Sena tend to add Kobato to the mix. The results, if in any way canon-inspired, tend to be hilarious.
Ship Sinking: In the final volume, to the rage of countless readers. Kodaka shoots down all the girls of the Neighbor's Club, with Yozora going last, primarily because starting a relationship with any of the girls would mean drastically changing the status quo of the club, and he didn't like the idea of that.
In other parts of the vast reaches of the internet, there's a battle brewing between those who prefer to see Kodaka with Yozora, and others who would rather see him with Sena. The other girls are largely relegated to Demoted to Extra status in this regard. Amusingly, Kodaka himself keeps letting it slip that Rika is really his type (or would be with a better personality, but that goes for all the girls).
If the events of volume 8 go unobstructed, seems like the joke's gonna be on Yozora fans. As of volume 9, the Sena ship has effectively been halted with a torpedo, letting the other ships close in, since Kodaka turns down Sena's offer of marriage.
Rika and Yukimura's ships seem to be gaining some steam with the second anime season. Volume 9 does little to stop them.