- Awesome Music: In the original film - "Opening," "Discovering the Neighborhood" and "Ryce's Theme," also the usage of "Roll Over, Beethoven"
- Fridge Brilliance: George initially believing Beethoven bit the vet makes sense when you consider Beethoven is a large, male, unneutered and ill-behaved dog.
- He Also Did: Charles Grodin is also well-known as a guest pundit on 60 Minutes.
- Hey, It's That Guy!: Floyd is played by Nice Guy Eddie.
- Retroactive Recognition: In the first movie, look out for a pre-Everybody Loves Raymond Patricia Heaton and a pre-The X-Files David Duchovny as a pair of con artists who try con George out of his air freshener business.
- In addition, in the second movie, a pre-That '70s Show Danny Masterson appears as Ryce's boyfriend. Ironically, Danny's younger brother, Christopher Masterson, later of Malcolm in the Middle fame, actually originally had a minor role in the film, but his scenes were deleted as the producers felt he looked too similar to Danny. (No one on set knew that they were brothers.)
- Stefanie Scott from Disney's A.N.T. Farm was the girl that the main star's son had a crush on in Big Break. She was nice unlike a few of her other roles.
- Unacceptable Targets: The American Veterinary Association wrote a letter to the head of the MPAA (Jack Valenti) about the main villain of the first film being a veterinarian.