These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
YMMV: As Good As It Gets
Anvilicious: Averted, for the most part. Despite absolutely crappy lives, mostly of their own doing, no one really gives anyone a 'Suck It Up' speech. The three main characters are their own worst enemies, effusive and self-destructive (and in Simon's post-hospital state, self-loathing)
Simon: Thank you, Melvin. You overwhelm me. (beat) I love you.
Melvin: I tell ya, buddy, I'd be the luckiest man alive if that did it for me.
Also, the scene in the main page's picture when Melvin picks up Verdell and everyone around him smiles as he showers affection on the dog. It's also a Crowning Moment of Funny, because he's doing that out of happiness that he'd trained the dog to avoid stepping on cracks.
Jerkass Woobie: Melvin. Even when he tries to be helpful, either in his own abrasive way or actually doing something kind all on its own, no one is ever grateful to him, they all treat him terribly because his mental illness bothers them, and they constantly demand he stop being so rude and confrontational to others while they feel no need whatsoever to be anything but horrible to him.
...then, after she rushes madly to her apartment to find that the doctor is there to her son, but nothing is particularly wrong with him at the moment, she is informed that the paediatrician has been sent to attend to her son by Melvin... a really creepy jerkass customer from work who has come dangerously close to being a stalker.