These are what we call the 'YMMV items.' Things that some people find in this work. We call them 'your mileage might vary' because not everyone sees these things in the same way. This starts discussions in the trope lists, a thing we don't want. Please use the discussion page if you'd like to discuss any of these items.
Anticlimax Boss: The final battle against his rival, Matt, in the Fire Red Nuzlocke, turns out to be pretty anticlimax.
Similarly, Drayden in Part 18 of the Black Nuzlocke. Gohma the Crustle uses two Shell Smashes and OHK Oes all three of his Pokémon.
Never Live It Down: Sigilyph was his "sworn enemy" of the Black Nuzlocke after it killed Elvis the Roggenrola in Episode 8. Snorlax was this of the Fire Red Nuzlocke when it killed Buzzinga the Beedrill in Part 12 with a critical hit Headbutt. And most recently, he hates Iron Island thanks to the wild Pokémon rule in the Platinum Insanity Nuzlocke.
Tear Jerker: Many of his deaths in his Nuzlocke series, including Allie the Krokorok in Part 16 of the Black Nuzlocke, and Annette the Flare Hawk and Sophia the Sky Ripper in Part 14 of the Ruby(?) Nuzlocke to name some. But that's to say nothing of the biggest one of them all: Morton the Gastrodon in Part 43 of the Platinum Insanity Nuzlocke, to a critical hit from Lucian's Bronzong.
What an Idiot: Some of the deaths in his Nuzlockes can be pretty frustrating to watch. Some people have even told him he has self pity for always calling himself stupid.