- Alternate Character Interpretation: A commentator on Mari Ness' Madeleine L'Engle reread for Wrinkle argues that Meg's character shows a "far better portrayal of a profoundly gifted child than Charles Wallace was."
- Big Lipped Alligator Moment: The stop on/in the two-dimensional planet.
- Covers Always Lie: The DVD cover features the three main characters on a winged horse above a medieval-looking castle, neither of which remotely resembles anything that appears in the film.
- First Installment Wins: Ever heard of A Wind in the Door, A Swiftly Tilting Planet, or Many Waters? None of them got Newbery medals.
- A Swiftly Tilting Planet did win the American Book Award in 1980.
- Fridge Logic: Wrinkle comes under scrutiny when the characters of When You Reach Me discuss it. Specifically, Miranda and Marcus discuss L'engle's portrayal of time travel. The three Mrs W's promise Meg and the boys that they should be back "five minutes before you left." But as Marcus points out, if this is true then Meg should have seen herself returning, because Meg&co. landed in the garden, which in plain sight from wall, where they left. Marcus is arguing a Stable Time Loop is in effect, while Miranda (very defensive of her favorite author) maintains that the future hadn't happened yet, so of course they wouldn't be seen.
- Fridge Brilliance: There is a simpler explanation, which no one in When You Reach Me notices: Mrs Whatsit says they'll be back five minutes before they left, unless "something goes terribly wrong." And something does indeed go terribly wrong.
- Genius Bonus: Camazotz is also the name of a particularly terrifying Mayan bat god. Ixchel, the planet of the angelic, sightless Beasts, is named, appropriately enough, for a Mayan jaguar god of medicine and rainbows.
- Hilarious in Hindsight:
- Tear Jerker: Meg has just recovered from her rough experience tessering through the Black Thing, and has been told that she has to go back. She briefly loses it, but quickly realizes that it has to be her — nobody else can save Charles Wallace. She starts saying her goodbyes and gets to her father:
Meg: I'm sorry.Mr. Murry: Sorry for what, Megatron?Meg: I tried to pretend it was your fault...I wanted it to be easy, I wanted you to do it all for me —Mr. Murry: But I wanted to do it for you. That's what every parent wants.
- Never Trust a Trailer: Much of what you see in the trailer is not what's in the movie, with some shots even ripped from other films!
- Viewers Are Geniuses: Scientists' reaction at the time of this book's first printing. They couldn't understand how something as advanced and theoretical as quantum physics and tesseracts could be accessible to children.