- Alternative Character Interpretation: A commentator on Mari Ness' Madeleine L'Engle reread for Wrinkle argues that Meg's character shows a "far better portrayal of a profoundly gifted child than Charles Wallace was."
- Big-Lipped Alligator Moment: The stop on/in the two-dimensional planet.
- Ensemble Darkhorse: Aunt Beast. A furry alien with tentacles who is blind, only communicates telepathically, and has bottomless love and empathy for Meg. She only appears in the last quarter of the book but makes a heck of an impression.
- First Installment Wins: Ever heard of A Wind in the Door, A Swiftly Tilting Planet, or Many Waters? None of them got Newbery medals. Some of this may have to do with the fact that most elementary or middle schools tend to make A Wrinkle in Time required reading at some point but not so much the others. And thus, the first book tends to be more ingrained in peoples' memories.
- A Swiftly Tilting Planet did win the American Book Award in 1980.
- Genius Bonus: Camazotz is also the name of a particularly terrifying Mayan bat god. Ixchel, the planet of the angelic, sightless Beasts, is named, appropriately enough, for a Mayan jaguar god of medicine and rainbows.
- Hilarious in Hindsight:
- Tear Jerker: Meg has just recovered from her rough experience tessering through the Black Thing, and has been told that she has to go back. She briefly loses it, but quickly realizes that it has to be her — nobody else can save Charles Wallace. She starts saying her goodbyes and gets to her father:
Meg: I'm sorry.Mr. Murry: Sorry for what, Megatron?Meg: I tried to pretend it was your fault...I wanted it to be easy, I wanted you to do it all for me —Mr. Murry: But I wanted to do it for you. That's what every parent wants.
- WTH, Casting Agency?: DuVernay has been adamant about casting a diverse cast in terms of race and gender, and for the most part the response to her choices has mercifully avoided the kind of Internet Backdraft usually associated with Race Lifting. That being said, some of the acting picks are rather...unorthodox.
- The choice of Reese Witherspoon and Mindy Kahling as two of the witches sparked some befuddlement, given how they're usually depicted as older women.
- The casting of Zach Galifianakis as the Happy Medium also caused a lot of head-scratching.
- To a lesser extent, Chris Pine and Gugu Mbatha-Raw as the Murrays. While no one doubts their acting abilities, they were seen as too young to play highly experienced scientists.
- Win the Crowd: The choice of Ava DuVernay as director got a lot of people excited for the film, particularly those who were disappointed that she passed on Black Panther.