Diary of a Wimpy Kid with the cynical humor of The Simpsonsnote or, in some cases, a G-rated Malcolm in the Middle, Regular Show's bizarre plots and unconventional character designs, the "cartoon characters in the real world" gimmick of Who Framed Roger Rabbitnote though it's more like the American version of Sit Down, Shut Up, in that the backgrounds are all live-action photos rather than moving footage, and the "characters animated in different styles and interacting with each other" gimmick of Drawn Togethernote only Amazing World of Gumball has more diverse animation styles, while Drawn Together used 2D animation and used styles from different eras of animation, like the 1920s Max Fleischer, 1960s Hanna-Barbera, and 21st century Flash animation.
The pitch pilot and original premise (about outcast cartoon characters being sent to a remedial school) played out like a "kids in school" sitcom meets Don Hertzfeldt's Rejected.
The Ren & Stimpy Show is Laurel and Hardy meets Bob Clampett's filmographynote for the original Nickelodeon version, both the John K. episodes and the Games Animation episodes and/or an adult underground comic book from the 1960s note for the "Adult Party Cartoon" episodes.
In its later years, it's become like post-cancellation Family Guy meets a more disjointed Robot Chicken meets MAD magazine at its worst.
Parodied on The Simpsons episode "Homer to the Max" (1999): The thirteen producers of Police Cops started out "with a singular vision" — Titanic meets Frasier — but it scared the hell out of them, so they threw together a cop show.
Steven Universe's dad looks like a mix between Homer Simpson (has the beard mouth, pear body, balding head, and legs and feet of Homer) and Carl (the white sleeveless T-shirt and shorts look like his white sleeveless T-shirt and sweatpants) from Aqua Teen Hunger Force.