In Unknown Armies, some characters (specifically television-obsessed Videomancers) can actually use Wrong Genre Savvy to their own advantage: a Significant formula spell from that school, called 'Laff Riot', literally replaces reality's normal rules with the conventions of a situation comedy ... "reality", here, being defined as the brutal and unforgiving harshness of a self-identified postmodern horror role-playing game of power and consequences wherein foolish characters often have the life expectancy of goldfish. The spell lasts only seconds in a fight or a few minutes outside of combat, but while in effect, all gunshots miss (including critical successes) and no physical damage from any source can exceed 5 points (approximately 1/10th of the average human's hit points). Targets of any attacks are, however, often subject to hilarious and humiliating pratfalls, like the suggested result of winding up hanging by the seat of your pants from a fire escape, flailing helplessly. Wrong Genre Savvy applies again when the spell wears off, of course, and people are once again free to plummet to their death.
Too much Talecrafting in Changeling: The Lost can cause a changeling to fall prey to this, his or her perceptions becoming warped to perceive everything as part of a fairy tale.
The Cyberpunk 2020 adventure module "Carlsbad Caverns'' features a vampire as the primary villain. Not a normal person who's been cybered with the appropriate implants to pretend to be a vampire, but an honest-to-God supernatural blood-sucking creature of the night. GM notes for this adventure module suggest that the referee allow the players to keep thinking they're in a gritty cyberpunk science fiction story, while they're actually being thrust into a gritty survival horror story.