* ''ComicStrip/{{Candorville}}'' was once a mostly realistic strip with the occasional BigLippedAlligatorMoment. Its [[GenreShift transition]] into a darker, more unnerving brand of humor can be traced back to the first time [[BlackAndNerdy Lemont]] and [[KnifeNut Saxon]] are alone together, when Saxon's mask of sanity begins to slip. Two lines cemented the change, and every subsequent plot arc can be traced back to them: "[[spoiler:The vampire, Roxanne, is not my lover. She's my mother.]]" Of course, this was aided somewhat by [[spoiler:Saxon's suddenly developing MilkyWhiteEyes and fangs]].
* ''ComicStrip/FunkyWinkerbean'': "That's because I was the one sending those texts to you."
* ''ComicStrip/RickOShay'': New preacher Jubah Lee notices Hipshot Percussion is the only town resident to not come to church. Visiting the gunslinger during his target practice, the preacher mentions how faith can give a person confidence. Hipshot explains he has all the confidence he needs, thanks. Preacher Lee replies "Oh? and is that the reason you practice with six guns two hours every day?" Stunned by the remark, an impressed Hipshot relents and goes to service the first time in his life.
* ''ComicStrip/ForBetterOrForWorse'': "I have fallen in love...but it's not with a girl."
** When Elly is informed after getting back from vacation that Kourtney has been fired in her absence.
* ''{{ComicStrip/Pogo}}'': "We have met the enemy, and he is us."
* From ''ComicStrip/{{Drabble}}'':
-->'''Norman:''' I never thought to ask you, Echo, what are you doing at this wedding?
-->'''Norma/Echo:''' Oh, I'm related to the bride.
-->'''Norman:''' What a coincidence. I'm also related to the bride.
-->''Cue simultaneous OhCrap looks.''
* {{ComicStrip/Retail}}: A challenge is declared. A plot to make a rival change jobs backfires horribly.
-->[[TheSlacker Cooper]]: *To [[InsufferableGenius Josh]]* Because, by this time next year, I'm going to have your job.
* ''ComicStrip/{{Garfield}}'': When Jon [[http://garfield.com/uploads/strips/2006-07-26.jpg confronts]] Liz on going out with another guy:
-->'''Liz's date:''' So, what a minute... you ''like'' this guy?\\
'''Liz:''' As a matter of fact, I do.\\
'''Jon:''' That's right! She does! ...You do?
* ''ComicStrip/CalvinAndHobbes'': "[[AdultsAreUseless Okay, quitter! Go home.]]"
* ''ComicStrip/BloomCounty'' sometimes had these, and usually played them for laughs.
-->'''Fundamentally Oral! Bill:''' ''[[DoesThisRemindYouOfAnything PENGUIN LUST!]]'' Nothing but urges from ''HELL!''
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