Grossology (2006-2009) is a cartoon series about a Brother-Sister Team, Ty and Abby, who solve all the Squick related problems in their town (within the confines of TV-Y7, of course). Based loosely on a series of books by the same name.
This series has examples of:
Adults Are Useless, especially in Fartor's case. His older brother farted in his face every day for thirteen years until he mutated into a methane reliant fart monster. Why didn't his parents do anything all that time?
Basso Profundo turns out to be just as skinny as he used to be, and the only reason he looked fat was because he had so much gas in him, which he lost over the course of his Burping Contest with Ty's and Abby's dad.
Expy: Any Kim Possible fan might see Labrat as a taller, skinnier version of Wade.
To say nothing of Abby as a junior-high version of Kim...who digs the gross stuff.
Fangirl: Abby was VK's fan. So much a fan that she refused to believe that VK was the culprit despite seeming evidence. Only when VK admits everything does she get over her fangirl-ness and stop him good.
Limited Social Circle: Subverted. Ty and Abby don't seem to have friends of their own. In "The Perfect Stink", their parents point out how they never see their friends around. The only friends they've ever meet are Naomi, Andy and Lab Rat.
Missing Episode: "Let Them Eat Fruitcake" and "Pucker Up" were delayed due to being holiday episodes (Christmas and Valentine's Day respectively), but due to the series' cancellation neither of them aired.
Both aired in Australia, but for unknown reasons the UK only got "Pucker Up".
Nephewism: In "Night of the Living Roadkill" the Director is shown to have a nephew. Though since this episode turned out to be All Just a Dream and he never shows up in any other episodes he might not really exist.
Speaking of, the lack of Vomit Indiscretion Shot in a Gross Out Show is, one assumes, a Y7-rating related issue. Which didn't stop the show doing an episode revolving around a puking spree (including Abbey puking for canonically the first time in her life), which made the Discretion thematically somewhat unfortunate.