No one really makes technology based off Epic powersThere's an obvious hurdle in emulating their powers, which is that they're explicitly physically impossible. Steelheart's most advanced equipment and the Reckoners' gear is based off Transference Epics. The arms dealer who provides highly advanced equipment takes payment in the preserved, still-living cells of Epics. This is supposedly for research purposes, but quite possibly has the real purpose of installing cloned cells into the technology, actually using their powers directly instead of merely imitating them. The gun he sells to the Reckoners may actually be an exception; it's a coilgun (so we know how to make it today, in theory) that shoots highly energized projectiles and has a higher power draw than Newcago. If that were representative of the difficultly of replicating Epic powers scientifically, it would not be a thriving research field.
Prof killed his fifth grade class by accident after the CalamityThat may be why he hates using his power so much. Using powers makes people more evil, and the manifestation of his powers might have made him lose control.
Prof made the DiggersIt's mentioned that the Diggers were gifted powers similar to the Tensor devices to dig underground. In the end, the Tensors are revealed to be Magic Feather s and Prof is really a Gifter Epic. Why he would do such a thing remains unclear.
Prof is afraid of the 'pattern' in Epic weaknesses because it means someone might find his. For someone that makes his life killing Epics, he's awfully insistent that there is no pattern. And he himself is an Epic, after all.