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This is a "Wild Mass Guess" entry, where we pull out all the sanity stops on theorizing. The regular entry on this topic is elsewhere. Please see this programme note.
The Adventures of Sherlock Holmes and Doctor Watson
This series is set in an Alternate Universe in which Holmes doesn't have a mood disorder.
Which changes a lot. He never developed a cocaine habit because he didn't have the incentive to self-medicate. His somewhat more amiable overall temperament in this adaptation is a combination of less hostile brain chemistry and the absence of the psychological side-effects of drug use.
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