Ichigo Mashimaro is a genderswapped, alternate universe of South Park.Think about it. While whatever town IM takes place in isn't as crazy as South Park, the interactions between the characters are similar. Just ignore the fact that they're all girls and are different ages.
Ana and her family are victims of brainwashing.How else would you explain that they act so stereotypically Japanese even when there are no others present? Alternatively, they are Japanese people that were subjected to nefarious genetic tampering to make them resemble gaijin. Whoever did it did not do proper research, therefore they look stereotypically blonde and blue-eyed, and are brainwashed into believing they are British people with un-British names who have adopted Japanese customs.
Nobue takes money from dirty old men with schoolgirl fetishes.In the anime, the official story is that she is twenty but looks sixteen. Yet we see her wearing a typical sailor suit school uniform in eyecatches. Since she is no longer in school, the most likely reason for doing this is to cater to someone's fetish. She does not have a boyfriend to please, and given that she is constantly hard up for money, it is likely she would dress up in order to earn money by "playing schoolgirl". For that matter, maybe her smoking habit is actually an euphemism for abuse of harder stuff, which would explain her money needs.
Miu's parents are never homeWe're not talking outright neglect here, but they both work full time and they've just fallen into the trap of working longer hours to ensure they can look after their daughter only to become distant through lack of time spent together. Miu is at Chika's house so often because she and Nobu are more like family than her parents to her, this also explains why she acts out, the classic negative attention is more desirable than no attention at all. We can also explain Miu's improbably large costume wardrobe in this way, an attempt by her parents to ensure she is happy while they can't be there for her.
Ichigo Mashimaro would be the Show Within a Show of Neon Genesis Evangelion, according to the respective page's theoryIf their favorite animes are about real life, and everybody's lives are screwed anough, they might find something with that Lolicon appeal at least endearing and Nobue is the nearest from the identificative character to themselves, thus, making Ichigo Mashimaro their favorite series of they all. Let's hope Barasui doesn't read it.
Sometime before Ch. 45, the Duke of Nuts rampaged through Hamamatsu.This caused a severe regionwide pudding shortage, and since Chika too suffers from a pudding deficiency, pudding quickly became Serious Business.