The main characters are all Clan Malkavian vampires from Vampire: The Masquerade...trying to escape from a lunatic asylum (and succeeding, at some indeterminate point in the story). The "Elf Tears" are human blood. Also, the "Weasel Emmisary" is a Clan Ventrue Camarilla vampire. Just because. This means the player character is Malkav/The Malkavian Madness Network.
They Are in The MatrixThis Explain the Super Powers
Team Sleuth and Mobster Kingpin are exiles.Specifically, from Prospit. Presumably, they were part of the troll's session.
Problem Sleuth takes place in the future after Homestuck
Alternatively, Team Sleuth and Mobster Kingpin have already played SburbAnd completed it. The passive and active players have been pitted against each other.