The end of the storyline will involve the creation of a Half-Human HybridYou have two young people forming a relationship under very unusual and treacherous circumstances. Furthermore, the Black Goat of the Woods with a Thousand Young (aka Shubby) is acting as the Dyer House den-mother, a mask of the Crawling Chaos is in close contact, and a Shoggoth Lord masquerading as a child, is living among them. The fact that the Sleeper of N'kai offered this to David shows that it is quite doable. It's either going to be her or Nancy with our young Mr. Bartlett that creates said offspring.
Theories about what the Deltas suspect David of beingCome on, I know you've got them. Let's hear them.
At some point time travel is going to be involvedIt's as good an explaination of why there's an ancient Egyptian tablet showing David telling off Set (who may or may not have been Nyarly) as any, particuarly since it's more or less supported by Word of God.
When the comic ends, David won't be human anymoreThe author has stated that there's going to be a Lovecraftian ending, of which there are three varieties; main character dies, main character goes mental, and main character becomes something else. Given that option three is both the most interesting and the most in keeping with the comic so far, this troper predicts that it'd going to happen. Strangely, given David's life so far, it could still qualify as a happy ending, for him at least.
Delta Green will eventually ally with the Dyer housemates against something worse
If/when Nancy discovers 'nookie' neither she nor David will be seen for a few daysBased on what happened with the pancakes, Nancy has some definite Sense Freak tendencies, not to mention being new to the entire concept of 'liking' something. Some things are just inevitable.
David's parents originally came from DunwichGoing by some comments of the author regarding certain future assumptions of David's parents regarding Shogga, I think it's safe to say that they're a special kind of stupid. Said variety of stupid seems to be endemic to Dunwich, at least it was back in the 1920's.