Dr. Zin's first name is Isaiah or Daniel.Jeremiah Surd and Ezekiel Rage are both named after Major Prophets of the Old Testament. Since Dr. Zin is the third major villain, he should fit the Theme Naming.
Jessie is the ancestor of Commander Jane ShepardOkay, admittedly, all I have backing this up is the hair, the voice, and the asskicking...but wouldn't it be awesome if it were true?!
Ezekiel Rage is actually perfectly sane.In one of the episodes featuring the villain, the Book of Rage he keeps rambling about is revealed to be his family photo album. He is not invoking some holy scripture when yelling about what "is written in the Book of Rage" but reminding himself of his loss. Drowning in his sorrow and hate, Ezekiel Rage finds the motivation to continue his Nihilistic/Misanthropic schemes. He started a cult because people with faith are capable of committing mass atrocities without hesitation, and are perfect for plans that call for the annihilation of the human race.