This is a "Wild Mass Guess" entry, where we pull out all the sanity stops on theorizing. The regular entry on this topic is elsewhere. Please see this programme note.
Grand Unifying Guesses Girl Genius aka: Girl Genius
Kim Possible: Dr. Drakken, Wade, and possibly Ron (based on his evil side), and Kim's little brothers. Kim is currently channelling her Spark in more athletic ways, but when she breaks through, she'll make her foes look like amateurs.