Lucas is bisexual.This sums up pretty nicely why Lucas is so obviously attracted to Cybersix's male alter-ego, and yet is also so obviously attracted to Cybersix as well. He's obviously attracted to Adrian, spending most of his free time hanging out with him and even asking him to go see a romantic movie with him- at this point, he's not even trying to hide it.
Lucas is trying to recreate SustenanceAn early episode of the animated series has "Adrian" walking in on him in the middle of an expiriment. When asked what he was working on Lucas quickly changes the subject. When we see his apartment it's obvious that he's been bringing his work home with him as a corner of his place shows a small but well stocked and recently used chem lab setup. He's seen the stuff before and even retained a sample of it for further study. He's probably keeping a very small vial of it hidden in a safe place so he can study it and free Cybersix from her violent lifestyle.
Cyber 6 was raised as a boy.Or at least, wasn't raised as a girl per se, not in the usual sense. In the photograph that shows Cyber 6 as a child, she doesn't look much like a girl at all. Since at young ages, boys and girls can be hard to tell apart, they are usually dressed in certain kinds of clothes to help differentiate between genders, but as a child, Cyber 6 still has the same short haircut and is wearing an ensemble you'd expect a boy to wear. While it's true that the reason she became the specific individual named "Adrian Seidalman" was based on circumstance, and she does identify as a woman, it would explain why she seems in general quite comfortable with living her everyday life as a man.
Data 7 doesn't require Sustenance.Just a theory, but considering the brain of Cyber 29 was transplanted into the body of a panther, abet a slightly genetically modified one, very feasible. There's not really much evidence to support it, but the show never seems to make any references to Sustenance outside of Cybersix's need for it, it seems strange they never bring up Data 7's dependence on it as well. Even in 'Final Confrontation', when Cybersix has her emotional monologue about needing it the way ordinary people need water, she only mentions that she needs it...Data 7's reaction could be easily read as momentary empathy rather than experienced sympathy. As far as I know, Data 7 was never mentioned as needing it in the comics either, which only gives the theory more credibility since the comic ran far longer than the cartoon.