Book Ends: The first boss, Simon Greedwell, is fought in front of a building's facade. He shoots the players from behind a barrier with mooks appearing from all directions to support him. The final boss, Sir Richard Rose, is fought under very similar circumstances, that is until you destroy his barrier.
Bowdlerise: The SNES version faced some censorship, including removing all references to alcohol, adding some modesty to the female NPCs, changing a boss' name from Chief Scalpem to Chief Wigwam, cutting his lines from "Me ready for pow wow!" and "Me pow-wowed out!" to "Ready for pow wow!" and "Pow-wowed out!" (though the subtitles say "Get ready for a pow-wow!" and "I'm pow-wowed out!") and replacing all the Native American enemies in one stage with white outlaws. Additionally, El Greco no longer says "Die, gringo!" before battle.
In both console ports, the female dynamite throwers are replaced with dynamite-wielding variants of the male bomb throwers.
In the Genesis version the player has to rescue a brown-haired girl in a yellow dress at the end of every odd-numbered stage. In a 2-Player game the player who gets to the girl first will receive the stage clear bonus.
Mad Bomber: The Smith Brothers. One of them has enough sense to talk, but the other is completely Axe Crazy. Their boss fight (the only one without a preceding stage) could be dangerous to play if you're epileptic.
Mirror Boss: Sir Richard Rose. After you destroy the barrier protecting him on his balcony, he'll to begin dash, jump and slide around the stage with agility that rivals that of the players. One difference is that his slide can do Collision Damage to the players.
Reformulated Game: The Genesis version is missing Steve and Bob, and only four of the arcade version's bosses are included. However, the stages are completely redesigned and are now divided into two segments, while the bonus rounds are different as well, so it's not a complete loss.
You No Take Candle: Dark Horse says, "You in big heap trouble!" when you fight him, and "Me in big heap trouble!" when you defeat him. Chief Scalpem also introduces himself with, "Me ready for pow wow!" and croaks, "Me pow-wowed out!" when defeated.