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In the first cutscene with Rhino, Spidey groans about having to face another of his old enemies, and wonders if the Hypno-Hustler (a lame one-shot villain in the comics) is next.
And at the end when Nick Fury gets all of the symbiote shards, he has the S.H.I.E.L.D. scientists study them for use. He calls it "Project Carnage".
Ninja Pirate Robot Zombie: The PHANTOMs, the main enemies throughout, are part robot and part symbiote alien. And some of them, depending on the place and type, are such combinations as robot-alien-samurai, robot-alien-mummy, and robot-alien-werewolf.