* FakeBrit - Canadian Creator/JenniferHale as the Scarlet Witch (who isn't British). Then again, Scarlet Witch was born and raised in a fake country. Who's to say what her accent sounds like? Also, her father, Magneto, doesn't even remotely sound Polish in ''any'' adaptation he's appeared in, including these games.
* CowboyBebopAtHisComputer: One of the trivia questions in the second game is to name which alien race the X-Men have never encountered. The in-game answer? Skrulls. This is in spite of the fact that at the time the game came out, there had already been ''two'' arcs where the X-Men had encountered the shape-shifting race[[note]]The first running through ''Uncanny X-Men'' #275-277 and the second going through ''Uncanny X-Men'' #368-370 and ''X-Men'' #88-90[[/note]].
* HeyItsThatVoice:
** Creator/PatrickStewart reprises his role from the [[Film/{{X-Men}} movies]] as Professor Xavier.
** Likewise, RobinAtkinDownes reprises his role from ''VideoGame/XMenNextDimension'' as Pyro and takes on the role of Cyclops in the first game (while absent in the second game, he'd later reprise the role of Cyclops in the first ''MarvelUltimateAlliance'' game).
** This series would also be the first time Creator/SteveBlum and Peter Lurie voiced their respective roles of {{Wolverine}} and Sabretooth, with both reprising their roles in ''MarvelUltimateAlliance'', ''WesternAnimation/WolverineAndTheXMen'' and ''WesternAnimation/{{Ultimate Spider-Man}}'' and Steve as Wolverine [[WesternAnimation/AvengersEarthsMightiestHeroes a]] [[HulkVS lot]] [[VideoGame/SpiderManWebOfShadows of]] [[TheSuperHeroSquadShow times]] [[VideoGame/MarvelVsCapcom3 since]]. Steve also voiced Omega Red in the second game and Peter voiced Avalanche in the first game, and [[ComicBook/AgeOfApocalypse Holocaust]] and [[TheOtherDarrin Blob]] in the second one.
** Creator/CreeSummer is Magma; while she herself wasn't in any prior incarnations of X-Men, her father, Don Francks, voiced Sabretooth in the 90s ''WesternAnimation/{{X-Men}}'' animated series.
** Creator/JohnDiMaggio is Juggernaut.
** Creator/JenniferHale is Scarlet Witch and the Stepford Cuckoos.
** Creator/JoshKeaton is Cyclops [[TheOtherDarrin in the second game]].
** Creator/EdwardAsner is Healer.
** Lou Diamond Phillips ([[StandAndDeliver Angel Guzman]]) is Forge.
** Creator/TaraStrong is Blink.
** Creator/TonyJay is Magneto in the first game.
*** Richard Green ([[WesternAnimation/TheBatman Hugo Strange]], [[WesternAnimation/TransformersPrime Skyquake]]) is Magneto in [[TheOtherDarrin in the second game]].
** John Kassir ([[TalesFromTheCrypt The Crpyt Keeper]]) is SelfDemonstrating/{{Deadpool}}, Pyro ([[TheOtherDarrin in the second game]]), and Sauron.
** Creator/KharyPayton is Bishop and Nick Fury.
** Creator/JamesArnoldTaylor is Iceman [[TheOtherDarrin in the second game]].
** Music/GreyDeLisle is Mystique.
** Dawnn Lewis ([[Series/ADifferentWorld Jaleesa Vinson-Taylor]], [[HanginWithMrCooper Robin Dumars]], [[WesternAnimation/SpiderManTheAnimatedSeries Terri Lee]]) is Storm [[TheOtherDarrin in the second game]].
** Danica [=McKellar=] ([[TheWonderYears Winnie Cooper]], [[StaticShock Frieda Goren]], [[WesternAnimation/YoungJustice Miss Martian]]) is Jubilee.
** Earl Boen ([[Franchise/{{Terminator}} Dr. Silberman]], [[VideoGame/MonkeyIsland the ghost pirate LeChuck]]) is Colossus in the first game.
*** Creator/JimWard is Colossus [[TheOtherDarrin in the second game]] and [[ComicBook/AlphaFlight Guardian]].
** Creator/DeeBradleyBaker is Nightcrawler and Multiple Man.
** Richard [=McGonagle=] ([[WesternAnimation/{{Ben10}} Four-Arms]], [[WesternAnimation/Ben10AlienForce some of the Highbreed]], [[WesternAnimation/StarWarsCloneWars General Grievous]]) is Apocalypse in the second game.
** Alastair Duncan ([[WesternAnimation/TheBatman Alfred Pennyworth]], [[VideoGame/LegacyOfKain Mortanius]], [[Franchise/MassEffect Councilor Sparatus]]) is Bastion.
** Masasa Moyo ([[CelebrityDeathmatch Tally Wong]], [[VideoGame/JadeEmpire Silk Fox]], [[JediStarfighter Adi Gallia]]) is Psylocke in the first game and Shanna The She-Devil in the second.
** Dorian Harewood ([[WesternAnimation/IronMan War Machine]], [[WesternAnimation/MegasXLR Ender]], [[WesternAnimation/TheBatman Martian Manhunter]]) is the Shadow King.
** Creator/ArminShimerman is Toad in both games and Zealot in the second one.
** Catherine Taber ([[VideoGame/KnightsOfTheOldRepublic Mission Vao]], [[WesternAnimation/StarWarsTheCloneWars Padmé]], [[VideoGame/TheForceUnleashed Leia]], [[VideoGame/FinalFantasyXII Penelo]]) is Rogue in the second game.
** Keith Ferguson ([[Franchise/KingdomHearts Marluxia]]) is Grizzly in the second game.
** Creator/KimMaiGuest is Lady Deathstrike and Shadowcat in the second game.
** Creator/QuintonFlynn is Banshee and Abyss.
** Creator/DwightSchultz is Garokk and the Living Monolith.
** Creator/DaveWittenberg is Archangel.
** Daniel Riordan ([[Anime/TransformersRobotsInDisguise Megatron]]) is Mr. Sinister and Stryfe.
* TheOtherDarrin: Several voice actors were changed from the first game to the second, but most of the changes were minor. Magneto, sadly, lost the magnificent baritone of Creator/TonyJay. Some of these were downright bad, particularly characters with accents like Rogue and Gambit, who had horrendous voices in the second game, though the latter case is odd, considering he was played by the same actor in both games.
* WhatCouldHaveBeen: DummiedOut content in the PC version of the second game indicated that Dazzler was planned as a playable character at some point.