- Fake American: Alexander Knox was Canadian. Also, Cedric Hardwicke, who played Henry Cabot Lodge, was a Brit.
- Magnum Opus Dissonance: After winning Best Picture for Gentleman's Agreement, Darryl F. Zanuck said on the Oscar podium that "I should have won this for Wilson".
- Playing Against Type: Fans of classic horror movies will be treated to a rare opportunity to see Vincent Price and Cedric Hardwicke in more straight roles, as Wilson's Treasury Secretary and primary rival, respectively.
- What Could Have Been: Dwight Frye was originally going to play Newton D. Baker, Wilson's Secretary of War. After Frye's untimely death, Baker was played by an uncredited Reginald Sheffield.