Trivia: What's New, Scooby-Doo?
- Acting for Two: Frank Welker voiced both Fred and Scooby in this series.
- Actor Allusion: In "A Scooby-Doo Valentine", Daphne laments that the fact that she was impersonated by an extra (who, ironically, resembled her voice actor, Grey DeLisle), saying "What, Sarah Michelle Gellar wasn't available?" Sarah Michelle Gellar played Daphne in the Live-Action Adaptation of the franchise.
- Hey, It's That Voice!: Several voice cast members from The Fairly OddParents can often be heard on this show; not only does Grey Delisle (Vicky) voice Daphne (having previously voiced the character in Scooby-Doo and the Cyber Chase), there have been several times where Tara Strong (Timmy), Daran Norris (Cosmo), Susan Blakeslee (Wanda), Carlos Alazraqui (Mr. Crocker), Kevin Michael Richardson (various other characters), even Adam West in one episode.
- The Other Darrin: After Don Messick's death, Frank Welker took over the voice role of Scooby-Doo, in addition to voicing Fred as he always did, which resulted in Scooby-Doo sounding more like Brain from Inspector Gadget. Velma was also recast to Mindy Cohn, which made her sound more like Mandy from Grim and Evil (ironically, Mandy was voiced by Grey DeLisle, who was Daphne's voice actress since 2001).
- Also, in The Vampire Strikes Back Kimberly Brooks did double-duty and voiced both Luna & Dusk of the Hex Girls (although the episode's credits claim that Dusk's usual actress, Jane Wiedlin from the Go-Go's, provided singing vocals).