As a loud, obnoxious children's show host with reality warping powers (and the voice of his rabbit sidekick, Loomis) on The Haunting Hour episode, "Uncle Howee" in one of the few times Tom Kenny has done work on a live-action show that wasn't a sketch comedy show, like The Edge and Mr. Show or a behind-the-scenes documentary where viewers get to see the men and women behind the voices of their favorite cartoon characters [i.e., I Know That Voice].
Played with a bit in Adventure Time. At first the Ice King seems like another one of his humorous roles, but then came The Reveal of Ice King's past which showed that he was once an ordinary guy by the name of Simon Petrikov, and he seems to be quite serious.
Woody Johnson on Brickleberry. While it is true that Tom Kenny has played a Fat Bastard (Heffer Wolfe from Rocko's Modern Life), it was Played for Laughs and Heffer being a bastard is more due to social ignorance than being a sociopath. Not the case with Woody Johnson. On top of that, the voice Tom Kenny uses for Woody Johnson doesn't sound like any character he's played before.