Executive Meddling: FOX wanted Erin and Titus to break up (a la Dharma and Greg), but Titus refused (as he based his show on real world events), which is how the show got canceled. Now considered Hilarious in Hindsight (in a dark and twisted way) in light of Titus's divorce from Erin Carden. The story of how Titus lost his show is explained on The Voice in My Head (and the story of how he lost Erin is detailed in Love is Evol and mentioned en passant in Neverlution and The Voice in My Head)
Erin's dad, Merrit, is played by Hamilton Camp (the voice of Gizmo Duck from DuckTales and a cast member on the failed 1969 sketch show Turn On)
Titus's dad is Mike Hammer (and was in the first Cheech and Chong movie, Up In Smoke, which explains the Running Gag on "Hard Ass" where Ken Titus confiscates teenage Christopher's weed and keeps it for himself [that, and the fact that Christopher Titus's father did smoke marijuana along with drink beer and smoke cigarettes])
Modern audiences will of course recognise Libby (Erin) and can get a taste of Frankie Muniz in the episode "Too Damn Good".
Missing Episode: Aired out of order, but you get the sense that they were changed because they were originally going to be taken out entirely, as both episode only aired at the end of the season; while there was only a light storyline, it still created some skewed continuity. They were held back because of how extreme the subject matter got.
"The Wedding" was moved five episodes down to the end of the second season because the episode involved domestic violence in a church (Juanita's boyfriend punches her in the face and Juanita shoots him).
"The Protector" takes place in the middle of the third season but was moved to the end (after the "Insanity Genetic" two-parter) because it dealt with child molestation ( Erin's niece Amy reveals that she was molested by a family friend who turns out to be the father of a boy who sexually harasses her at school).
Played straight with Titus's mom, who was played by three different actresses during the show's short-run, as well as the psychiatrist dating her who only appeared in two episodes.
Averted with Erin's family, as all of them were played by the same actors in such episodes as "The Perfect Thanksgiving" and "Deprogramming Erin" (though Amy didn't appear in "The Perfect Thanksgiving").
Screwed by the Network: Became one of the many short-lived replacement shows for Family Guy when Family Guy got UnCancelled and Peter named off all the shows that aired en lieu of their show between 2002 and 2005 on the episode "North By North Quahog."
Too Soon: Averted, as they portrayed the family being mistaken for terrorists on an airplane only several months after 9/11. From the DVD commentary: "If we're not funny, the terrorist win."