Creator Killer: And how! Not only did it's failure shut down Fox's barely-new animation studio, but also proved to be the final straw for Don Bluth, who retired from filmmaking after years of disappointment from Hollywood.
The sad part is neither film won, despite both of them being very good; in fact both ended up tanking their respective studios. Bluth has yet to produce a new movie in 11 years, and Disney almost decided to completely abandon traditional animation.
Executive Meddling: Fox Animation Studios is blamed by the directors in the DVD commentary for starving the movie of both time and money, forcing them to produce a product they were not happy with; as a result the film is unfinished at best.
The Foreign Subtitle: As the initials for A.E. were difficult to properly translate, in some places the movie was just named Titan with the following subtitles:
After the Destruction of Earth (Portugal/Croatia) [a little wordy, but probably closer to the English title than the other two]
In the DVD commentary, one of the directors joked about making a spin-off movie starring Gune. The other director said that he liked the idea. Of course, whether-or-not he would have followed through with it, the film's box-office failure killed any chances of that.
According to the DVD's behind-the-scenes special, Drew Barrymore played Akima as a more feminine and inexperienced/naive character. The directors eventually decided they weren't happy with it, and the lines were re-recorded (or, in some cases, thrown out and rewritten). In an interview, Barrymore implied that she liked the original characterization better.
There was originally going to be a video game based on the movie that would have come out after the movie hit theaters. At the end of the credits, there's even a brief message from the creators, telling viewers to look out for it when it hit stores. Seeing the message can be a bit baffling today, since the movie's box-office failure meant that the game never got made.