- Actor Allusion: Eva Gabor is from Hungary, which happens to be the country Bianca represents at the Rescue Aid Society.
- Bowdlerization: In two frames of the movie in its theatrical release, when Bernard and Bianca are riding Orville, going down from the building they were on, one building next to them has an image of a live-action naked woman in one of the windows. Disney found this out prior to the film's initial VHS release and had the images removed (all subsequent home video releases, except the early prints of the 1998 VHS and Laserdisc, feature the edited version). According to animator Tom Sito, on his Facebook page, the image was put in by background artist Annie Guenther.
- Creator Backlash: Animator Don Bluth was said to have finally had enough of Disney repeatedly falling short of their reputation with this film and, shortly thereafter, lead an infamous mass exodus of animators to his garage-based studio. He later said that he was especially livid about the main characters' eyes not being colored in.
- Cross-Dressing Voices: Bizarrely, the Italian dub had Penny voiced by a young boy.
- What Could Have Been:
- The movie was originally a very different movie than what was released. It was going to be a vehicle for Louis Prima (King Louis of The Jungle Book), playing Louie the Bear, and, according to the video in the link, to be about a Bear using a pair of mice to help him escape from the zoo and to save his friends at the North Pole. This version was scrapped shortly before Prima lapsed into a coma and it was Retooled into the movie we know today.note
- Also, before it was completely retooled, the movie's antagonist and villain was originally going to be Cruella DeVille. In fact there is a bit of a Development Gag there - Madame Medusa not only drives very similarly to Cruella, but also her jet ski looks to be inspired by Cruella's car.
- Less a development gag and more the result of one animator's insane jealousy. Milt Kahl, one of Disney's Nine Old Men, had been insanely jealous of his colleague Marc Davis's animation of Cruella and Medusa was his attempt to finally "outdo" him.
- In the planning phase, Orville the albatross was originally a pigeon.
- Early drafts of the movie involved saving a polar bear from a tyrant penguin. Not sure how the finished product would have been.
- Yet another draft would have been rescuing a depressed poet from a prison, which follows the book "The Rescuers", but in the end they followed the sequel "Miss Bianca" more closely.
- Originally, Chip 'n Dale Rescue Rangers was supposed to be a Rescuers TV series. Consider the expies:
Chip + Dale = Bernard
Gadget = Bianca
Monterey Jack = Jake
Zipper = Evinrude the dragonfly
- Had Penny not been replaced with Jenny, Oliver & Company would have instead been Disney's first sequel/spin-off in the canon, preceding Down Under by two years.
- The producers intended for the popular 1970s pop duo Carpenters to do the movie's music, but scheduling conflicts forced them to reluctantly decline. Having to turn it down was especially hard for Karen Carpenter to do, as she was a big fan of Disney.
- Even after it was Re Tooled away from being a vehicle for him, Louis Prima was still going to be in the movie with his intended character reworked. In the original draft, Bernard and Bianca were going to talk to Louis the Bear about Penny where he revealed she came to the zoo often. He also sang a song called "Peoplitis". It may have been cut for time as Prima did record the song and, presumably, his lines.
- Brutus and Nero were initially going to be alligators according to the concept art◊, before the film officially identifies them as crocodiles.
- Madame Medusa's jet ski, or "swampmobile", appears to be powered by a jet engine. This is evidenced by the jet engine-like rear exhaust and the distinctive jet noises the vehicle makes. However, in a later scene in the film, a normal four-stroke engine is shown to lurk under the hood at the front.
- Joe Flynn died unexpectedly in 1974, three years before this film was released. The voicework for the film was done around 1973.