The Danza: Besides George O'Hanlon as George Jetson, D.J. Rick Dees has a small role as "Rocket Rick", who is also a D.J.
Executive Meddling: Janet Waldo had already recorded her lines as Judy Jetson only to get bounced from the movie in favor of late 1980s pop star Tiffany. Waldo has said she found out shortly after the decision was made, and it was highly publicized. She was pretty upset at first, but has admitted it's become a non-issue, and doesn't hold any ill-will against anybody, not even Tiffany. In an odd twist of irony, Tiffany grew bitter with Janet Waldo because of her ever showing resentment to being replaced. It didn't even work out for the studio. Animation Lead Time meant that while Tiffany was huge when they cast her, her fifteen minutes of fame were pretty much over by the time the film actually came out.
Franchise Killer: Coming on the heels of the 1980s Jetsons revival (the new syndicated episodes and two TV movies), this film's disappointing box office and harsh critical reviews were apparently enough to send the franchise back into hibernation. It has stayed there ever since, a potential live-action film being stuck in Development Hell for years notwithstanding.
If you're a Mystery Science Theater 3000 fan, chances are you might recognize Cosmic Cosmo's voice as the same singer that Mike and the Bots mercilessly mocked during the end credits of Space Mutiny for the fact that the song he was singing was so blatantly 80's.
The Other Darrin: Pretty much everybody except Jane. Daws Butler (Elroy) died a year before the movie started production, so he was replaced by Patric Zimmerman. Mel Blanc (Mr Spacely) and George O'Hanlon (George) died during production, so the few unrecorded lines they had left were done by Jeff Bergman. And most infamously, Tiffany replacing Janet Waldo (Judy) after the latter had already recorded all her lines for the film.