* This was the only Creator/{{Compile}} game distributed by {{Broderbund}}, but Compile had previously developed ports of Brøderbund's games ''A.E.'', ''VideoGame/{{Choplifter}}'' and ''VideoGame/LodeRunner''/''Championship Lode Runner'' for the {{MSX}} and/or Sega SG-1000.

* FanNickname: Some fans, not content to use the Guardian's codename for her (and not realizing the Japanese manual gave her the name Miria) have taken to referring to her as Alyssa or rarely as Irem.
** The game itself is occasionally referred to as "[[EyeScream Eyeballs: The Game]]" because of the many eye-related monsters.
* SequelFirst: More precisely, GaidenGame first. The original ''Guardic'' was a Japanese-only MSX game.