- Throughout the series, there are direct and indirect references to the movie Friday, which starred John Witherspoon, the voice of Robert "Granddad" Freeman.
Granddad:: That wasn't even me. That's that nigga from Friday dressed like me.
- In "A Date with the Health Inspector", Rummy (voiced by Samuel L. Jackson) demands to know if they speak English in a mysterious country known simply as "What." On the way to the real Xbox killer's apartment, Ed and Rummy stop to get a "tasty beverage." One gets the impression that Rummy is a big Pulp Fiction fan.
- Mark Hamill plays a dealer who sells Granddad something called "Skywalker" and Black Pearl.note
- Rev. Rollo Goodlove messes up while singing "Go-Go Gadget Gospel," a song originally performed by his voice actor Cee-Lo Green. It becomes even more funny when you realize Green is purposefully messing himself up when he should be able to sing it perfectly.
- "I Dream of Siri" has Grey DeLisle portray an mentally unstable female, albeit it was piece of machinery. The role echos her portrayal of Azula.