Adored by the Network: St. Elsewhere was NBC executive Brandon Tartikoff's favorite show, a fact which saved it from cancellation a couple of times.
The Danza: Florence Hufnagel and Murray Robbin have the same first name of their actor/actress.
Directed by Cast Member: Eric Laneuville (Luther Hawkins) frequently stepped behind the camera starting in season 2. William Daniels and David Morse also directed a few episodes.
Executive Meddling: A rare example with positive results. NBC executive Brandon Tartikoff was a huge fan of the show. His favorite character was Dr. Morrison, and he would frequently return scripts to the writers with "More Boomer!" written across them. This led to some of the most emotionally powerful moments on the show, as explained under Butt Monkey.
Life Imitates Art: In the episode "Fathers and Sons" the moving man for Dr. Westphall says "Dad says we're on the cusp of a complete monetary disaster. The problem with the banks and corporations is they got debts up the wazoo, no way they're ever gonna pay it off. If you think '29 was a mess says Dad, wait till you see the sidewalks of Wall Street in two years tops." This episode aired September 25, 1985. Black Monday was October 19, 1987, so he was off by less than a month.
Name's the Same: Searching on YouTube for St Elsewhere videos often leads you to recordings of a song by Gnarls Barkley, which has nothing to do with the show.