Trivia: Space Chimps
- Actor Allusion: Ham III is basically Rod (from Hot Rod) as a chimp - both are played by Andy Samberg.
- Creator Killer: The sequel's critical and box office failure killed its animation studio.
- Hey, It's That Voice!: Patrick Warburton is Titan.
- The Other Darrin: In the first film, Ham was voiced by Andy Samberg. In the second one, Tom Kenny took over.