Adored by the Network: Ever since King of the Hill ended after 12 years on the air and Sit Down, Shut Up flopped so badly that it was canceled after four episodes (along with other animated shows that got the shaft after a short run, like Allen Gregorynote even though viewer and critic opinion of the show is that it sucks and should not have been made and an animated version of Napoleon Dynamitethat came five years too late), the Sunday night "Animation Domination" line-up is mostly made up of Seth Mac Farlane's cartoons (even with The Cleveland Show canceled, there's still Family Guy and American Dad!, though as of the 2014-2015 season, Family Guy is going to be the only one left because American Dad is moving to TBS). Currently, the only cartoons that aren't created by Seth Mac Farlane on the "Animation Domination" line-up are The Simpsons, Bob's Burgers, and an upcoming animated series in 2015 called Bordertown, which was created by Mark Hentamennnote Mark Hentamenn was a writer and producer of Family Guy in its pre-2002 cancellation days and was the man behind the short-lived MTV animated show 3 South, about a Harvard-bound college student who ends up in Barder College, the most corrupt, anti-intellectual college in the country after Harvard reaches its quota of white males (though MacFarlane has a producer credit on the show).
Real-Life Relative: His sister, Rachael, also does voice-acting on his shows (the voice of Hayley on American Dad and regularly contributes additional voices to the other shows).
Screwed by the Network: Family Guy was subjected to this back in the late 1990s/early 2000s. American Dad! has been this way as well, especially ever since Family Guy was Un-Cancelled (Family Guy even has jokes about American Dad! being nigh-unknown, such as Peter referring to the show as "...whatever FOX is limping to the barn with," and in American Dad!, Brian Griffin stares at Stan and scoffs, "Do I know you?"). Amazingly, The Cleveland Show wasn't subjected to this treatment, despite the fact that most Seth MacFarlane fans don't care much for this show — however, on April 2013, Fox still cancelled the due to low ratings and the popularity of Bob's Burgers.
Marth Debuted in Smash Bros.: His film Ted is the first time that anything created by him has been shown in Japan, since none of his famous shows are broadcasted there.
Played straight in Family Guy and American Dad!, where Seth voices the father of the family (Peter Griffin and Stan Smith), the bizarre live-in guest (Brian the talking dog and Roger the alien), the next door neighbor with a sexual side (Quagmire the sex addict and Greg Corbin, a male homosexual in a committed relationship), and a news caster (Tom Tucker and, again, Greg Corbin).
Downplayed and subverted with The Cleveland Show: MacFarlane only played two characters on the show (Tim the Bear and Dr. Fist), who were later replaced with other actors (Jess Harnell played Tim the Bear during the show's final episodes and Dr. Fist was voiced by Tom Kenny in one episode and Bryan Cranston in the show's last episodes).
Parodied and deconstructed on his Saturday Night Live monologue where he states that the many vocal impressions he does are in his head all the time and a possible sign of mental illness.
What Could Have Been: Originally, MacFarlane was hired to do cartoon shorts for the FOX sketch show, MADtv, but backed out in favor of doing his own series. Had he chosen to do work for MADtv, he would have been just like Matt Groening and created Family Guy as filler for a sketch show, just like Groening did with The Simpsons for The Tracy Ullman Show.
Also, originally: The Simpsons was going to be canceled after 23 years and Seth's revival of The Flintstones was going to take its place. This fell through when MacFarlane decided to put his Flintstones revival on hiatus and The Simpsons was renewed for two more seasons in exchange for extensive budget cuts for cast and crew members in order to keep the show afloat.
Write What You Know: One of the main reasons MacFarlane chose to make Family Guy a series was the fact that, up until the late 1990s, there was little to no TV shows that took place in the New England states.