Creator Killer: Disaster Movie was their only movie to bomb both critically and financially, and since then, their output has been far more sporadic.
Genre-Killer: You could argue that the spoof genre would have died out in the late 2000s regardless, as audience tastes moved to "bromance" films, ensemble pieces and more intellectual comedies, not to mention the rise in popularity of quickly-produced (and, therefore, more topical) web-based comedy, but Seltzer and Friedberg helped completely drive the genre into the ground, with Disaster Movie being seen as the one that officially signified its death. These days, most spoof movies are relegated to Direct-To-Video.
Meaningful Release Date: In Disaster Movie, the world is set to end on August 29, 2008 — the very same day that the film opened in theatres.
Not Screened for Critics: A tradition for each film, and considering the rather vicious reaction the films tend to get, rather unsurprising.
Production Posse: Usually includes Jerry P. Jacobs and Peter Safran as producers, with regulars like Ike Barinholtz, Crista Flanagan, Carmen Electra or Diedrich Bader as actors.
Pixel Magic serves as their usual visual effects contractor.
Reclusive Artist: Other than the movies, we don't really know anything about these guys. All we have are two pictures circulating around the Internet, a couple of interviews, and some audio commentary on their movies' DVDs (which is apparently very cryptic and has almost nothing to do with their movie.) Seltzer and Friedberg finally gave an interview with Grantland in 2014.
What Could Have Been: The duo were the first choice to write and direct Scary Movie 3, but turned in a script that barely parodied horror films at all, and instead mostly spoofed Harry Potter and The Lord of the Rings. In the duo's defence their script was written in 2001, which was an awful year for the horror genre, but the studio quickly realized that they were more interested in just getting cheap laughs from whatever happened to be popular rather than sticking to what they were actually meant to be spoofing, resulting in them being canned and replaced by David Zucker.
At one point, they were developing a straightforward Liberace biopic.