Trivia: Scooby-Doo on Zombie Island
- Celebrity Voice Actor: Adrienne Barbeau provides the voice of Simone. She later branched out and did more voice acting in the years after this.
- First Installment Wins: Of a sort. This is the most popular Direct-to-Video Scooby Doo movie among fans.
- Hey, It's That Voice!: Frank Welker reprises his role of Fred Jones, and is the only pre-A Pup Named Scooby-Doo voice actor in the cast.
- In Memoriam: To Don Messick, the original voice actor for Scooby-Doo who had passed away the previous year, just before recording began.
- Keep Circulating the Tapes: The two Skycycle songs were never properly released (a hokey synthesized version appeared on the soundtrack for Scooby-Doo! and the Witch's Ghost). Better make friends with someone who knows how to mix out sound effects and dialogue!
- The Other Darrin: Scooby, Shaggy, Daphne, and Velma all have new voice actors (Shaggy is voiced by Billy West, and Velma's actress had previously provided vocals for a Johnny Bravo/Scooby-Doo crossover).
- Recycled Script: The concept was originally a unfinished SWAT Kats episode, "The Curse of Kataluna" (which would've involved a Succubus). Suddenly, the Darker and Edgier tone (and all the cat-related motifs) makes a lot more sense. (Parts of it were also recycled by the writer, Glenn Leopold, for a season two ep, "Eclipse", of Jonny Quest The Real Adventures.)
- What Could Have Been: Tara Strong says that she and the other voice actors were originally going to speak in Cajun accents. She herself says she found the accent very difficult and Jim Cummings (who is Cajun) said they didn't sound authentic, so they just went with typical Louisiana accents.