Fake Nationality: The actor who portrays Barry in the original FMV sequences (and in-game; he's the only actor to do both the FMVs and provided a in-game voice) is Norwegian, while the in-game voice for Jill (Una Kavanaugh) is Irish.
Barry Gjerde, Barry's voice actor, played the lead in Clock Tower and played Red in Mega Man X7.
Throw It In: Real Survival mode in the REmake. By default, all item boxes are linked so you can get your items anywhere and there's auto aim (although this was not present in the original game). According to the description of Real Survival, the prototype of original game had it where the item boxes weren't linked at all. The game mode emulates this and manual aim for the Challenge Gamer.
Vapor Ware: The Gameboy Color port was very near to completion when it was canned. Naturally, the ROM image eventually found its way to cyberspace, so even though it was never released it's still possible to play it.
What Could Have Been: In what would become a tradition for the series, the game had several differences from the drawing board to the beta version to the final version:
The game was originally conceived to be played from a first person perspective.
The infamous hallway where the zombie dogs burst through the windows had a giant spider crawling along the ceiling instead in the beta, changing the tempo of the horror considerably.
This player actually ran into a giant spider (or was it two?) going through that hallway after returning to the mansion when the Hunters showed up.
There was originally going to be an African American character named Dewey who was going to be comic relief.