- California Doubling: The movie popularized the use of Canada for portraying USA in film.
- Creator Backlash: John Frankenheimer battled alcoholism throughout the shoot and later blamed himself for the film's worst elements (including the decision to make the Kahtadin a mutant bear instead of the chimera-monster implied in the script). In retrospect, Prophecy was also a minor Creator Killer to the extent that it relegated Frankenheimer to paycheck films and direct to video work through the '80s and '90s. On the other hand, Armand Assante remains proud of his work on the movie.
- Fake Nationality: Plenty of the Native Americans are played by US or Canadian actors.
- Similarly Named Works: With the religious horror film The Prophecy.
