* TheCharacterDiedWithHim: Sort of. Snowball's last appearance, in which he was [[spoiler: turned into a regular hamster]] was aired around the time of his voice actor's death. In essence, Snowball has been defeated for good.
* FakeBrit: RobPaulsen as Pinky.
* FranchiseKiller: What happened when ''WesternAnimation/PinkyElmyraAndTheBrain'' came in.
* WriterRevolt: "You'll Never Eat Food Pellets in This Town Again", "Pinky and The Brain... and Larry!" and the opening theme to ''Pinky, Elmyra & The Brain''.
* WhatCouldHaveBeen: The show was slated to air on Creator/TheHub in late 2014, but due to the change to Discovery Family, it never came to be.
* WritingByTheSeatOfYourPants: According to one of the head writers, Charles M. Howell, each of the 52 half hour episodes only had one week to prepare a script for them. Despite this, they ended up going four months over schedule.