Ink-Suit Actor: The ice cream man in the first episode is heavily modeled on creator Rob Renzetti.
The Other Darrin: In the episode "Around the World in 50 Pieces", Vexus is voiced by Cree Summer (who also voices Tiff). Eartha Kitt returns to form in the TV Movie.
Rule34 — Creator Reactions: When there was a debate on Facebook over this◊ fan-art of Jenny (SFW), Rob stepped in and offered his viewsnote "Let me say that this particular piece of art is okay with me. It is 'sexy', which is okay with me. What I object to is 'Sex' images where things range from very suggestive to completely explicit. I hope that is clear enough for everyone but, if you aren't sure whether an image might be appropriate or not, then don't post it.", saying that while outright porn of his characters wasn't tolerable, simple "sexy" pinups were A-OK.
Screwed by the Network: Nickelodeon once ran a poll between this show and Invader Zim to determine what would be shown next. Despite My Life as a Teenage Robothaving a clear lead, Nickelodeon declared Invader Zim the winner.note Though the show did air on said network, albeit as a 4 episode mini marathon in the wee hours of Thursday morning each and every week.
The second season was delayed for many months. And after lack of adverts, the third season didn't air for years after the show was canceled.