Cross-Dressing Voices: In some episodes of the Russian dub of season 3, Sheldon is voiced by a woman, while XJ-4 through XJ-8 are voiced by a man.
Ink-Suit Actor: The ice cream man in the first episode is heavily modeled on creator Rob Renzetti.
The Other Darrin: In the episode "Around the World in 50 Pieces", Vexus is voiced by Cree Summer (who also voices Tiff). Eartha Kitt voices her in every episode before and after, so this was probably because they didn't want to contact her for such a brief speaking role.
There's also a few episodes where Summer voices Vexus, but only in teenage forms.
In the Russian dub, some of the episodes of season 3 have almost everyone's voice replaced, with Tuck and Nora Wakeman sounding closer to their English voices, while Jenny's voice was made high-pitched and squeaky.
Rule 34 – Creator Reactions: When there was a debate on Facebook over this◊ fan-art of Jenny (SFW), Rob stepped in and offered his viewsnote "Let me say that this particular piece of art is okay with me. It is 'sexy', which is okay with me. What I object to is 'Sex' images where things range from very suggestive to completely explicit. I hope that is clear enough for everyone but, if you aren't sure whether an image might be appropriate or not, then don't post it.", saying that while outright porn of his characters wasn't tolerable, simple "sexy" pinups were A-OK.
Screwed by the Network: Nickelodeon once ran a poll between this show and Invader Zim to determine what would be shown next. Despite My Life as a Teenage Robothaving a clear lead, Nickelodeon declared Invader Zim the winner, even though both shows got screwed over by Nickelodeon, making the entire poll a farce.note Though the show did air on said network, albeit as a 4 episode mini marathon in the wee hours of Thursday morning each and every week.
The second season was delayed for many months. And after lack of adverts, the third season didn't air for years after the show was canceled.
Talking to Himself: In the Russian dub, Jenny and Tuck have the same voice actress, even after the voices were replaced in some season 3 episodes.