Trivia: Muppet Babies
- Cross-Dressing Voices: Rowlf (Katie Leigh), Gonzo (Russi Taylor), and Skeeter (originally Howie Mandel). Oddly, this is one of the very few times where this isn't the case for Piggy.
- Hey, It's That Voice!: Many viewers likely didn't realize it, but Nanny was voiced by Barbara Billingsley (June Cleaver on Leave It to Beaver).
- Baby Gonzo is voiced by Russi "Minnie Mouse" (or "Martin Prince," if you're a Simpsons fan) Taylor.
- In the first two seasons Howie Mandel is the voice of Animal, Skeeter, and Bunsen.
- Skeeter sounds like Gizmo, who sounds like Bobby Generic, who sounds like Howie Mandel on helium.
- Frank Welker is Kermit and Beaker.
- No Export for You and Keep Circulating the Tapes: There are no plans announced for any formal DVD releases of the show; no official reason has been given, but it's most likely due to copyright issues (due to the huge amount of Stock Footage used in the imagination sequences). However, now that Disney owns the trifecta of The Muppets, Marvel Comics (who produced the show alongside Jim Henson) and Lucasfilm (where a lot of the problematic footage came from), there may well be some hope.
- The Other Darrin: Frank Welker replaced Howie Mandel as Skeeter's voice midway through the show's run. Dave Coulier replaced Mandel as Animal and Bunsen.
- Talking to Himself: For the first two seasons, Howie Mandel voiced Skeeter, Animal and Bunsen. Frank Welker voiced Kermit, Beaker, Skeeter (taking over for Howie respectively) and various other voices. Dave Coulier also took over for Howie respectively, voicing Animal and Bunsen, as well as voicing Bean Bunny, Janice, Statler and Waldorf. Greg Berg voiced Scooter and Fozzie. Russi Taylor voiced Gonzo and Robin.