Creator Backlash: Faye Dunaway regrets having played Joan Crawford in the movie version and doesn't like to talk about it, either. Christina Crawford also regretted it being made.
Genre-Killer: While the book spawned a slew of nasty tell-all "memoirs" by children of famous celebrity parents that continues to this day, this film seemed have killed the idea of turning those books into major motion pictures, save for a television movie every now and then.
Parody: MAD Magazine referenced Mommie Dearest in their After the End satire of Who Framed Roger Rabbit from issue #284. With Roger's career already in decline, his daughter adds to his problems by publishing a tell-all book called "Bunny Dearest: A Hare-Raising Shocker".
Robin Williams also parodied this in one of his stand-up comedy routines that he called "Daddy Dearest", in which his hypothetical child berates his father's performance in the movie version of Popeye.
Parody Retcon: The movie started being advertised as a parody a few weeks after its release. Posters were changed to read, "Meet the biggest MOTHER of them all!"