- The Other Darrin: In the final season, they couldn't get the actor who originally played Allison's brother to come back, so they got Patricia Arquette's actual brother instead. Fitting, but a number of fans complained that he didn't look much like the original actor.
- Real-Life Relative: Patricia Arquette's then-husband Thomas Jane shows up as the ghost of Allison's old high school boyfriend; and in another episode, her sister Rosanna Arquette plays a murder suspect. Her brother David Arquette has also directed three episodes, and once filled in as her brother.
- Real Life Writes the Plot: Ariel went to college because, well, her actress went to college. Surprisingly she claims more people recognize her from Eloise than Medium or My Sister's Keeper, where she had to shave off her hair to play a cancer patient.