Trivia: Mary Shelley's Frankenhole
- Actor Allusion: Jesus is wearing a court-appointed alcohol monitoring bracelet around his ankle because his voice actor, Andy Dick, was wearing one in the studio when he came in to do his lines.
- Banned Episode: The second episode "Mother To Be-sa" was banned for reasons unknown (most likely content that not even [adult swim] would have found acceptable).
- Hey, It's That Voice!: Jeff Davis is Dr. Frankenstein.
- Pete Hornberger is Polidori, Frankenstein's Creation, and Gustav, one of Victor's sons.
- Elizabeth is played by Bloberta on Moral Orel (Britta Phillips) and the singing voice of Jem. That is truly outrageous. Truly, truly, truly outrageous.
- David Cross plays John Belushi and Jim Belushi.
- Andy Dick plays Jesus.
- Ken Jeong is EVERYBODY (including the Vanity Plate) in "Hyralious, Mutant Monster!"