* BoxOfficeBomb: The film proceeded to tank big-time on its opening weekend, and is now officially one of the biggest box office bombs ''ever'' and one of the two finalists to be the biggest animated box office bomb of all time. It scored the 12th worst opening for any film opening in 3,000+ theaters ($6 million) and suffered a net loss of over $110 million due to its $150 million budget and grossing only $39 million ''worldwide'' even with 3D grosses. Disney [[CreatorKiller shut down Image Movers]] shortly ''before'' it was released.
* CreatorKiller:
** The spectacular failure of the film lead to Disney shuttering Creator/RobertZemeckis's studio and canceling their next projects, a remake of ''WesternAnimation/YellowSubmarine'' (because he was only a producer, Zemeckis' directing career was spared) and ''Calling All Monsters'', a GenreThrowback to {{Kaiju}} films.
** While Zemeckis survived, director and Creator/DreamWorksAnimation alumnus Simon Wells and co-producers Steve Starkey and Jack Rapke ultimately did not; Wells has not directed or written another film (and his screen credits past this are as a story artist for DWA's films), while Starkey and Rapke's careers began fading off of Earth over the next year.
* DawsonCasting: Played straight and averted at the same time for the same character. Creator/SethGreen, who does the motion capture for Milo, was supposed to voice the character as well. However, his attempt at voicing a little kid didn't sound too good, so Milo is voiced by the much younger Seth Dusky.
* GenreKiller: Its flopping spelt the end to MotionCapture animated films. The sequels to ''WesternAnimation/TheAdventuresOfTintin'', released shortly after, have yet to see the light of day as a result despite that film being successful.
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