Ryder is voiced by MC Eiht (fans will recognize his "g'yeah").
Faizon Love — Big Worm from Friday — is your brother Sweet.
Samuel L. Jackson and Chris Penn play the villains, Officers Tenpenny and Pulaski respectively.
Peter Fonda is The Truth, David Cross is Zero, James Woods is Mike Toreno, Ice-T is Madd Dogg.
The DJ for the Classic Rock station (K-DST) is voiced by Axl Rose, who often takes shots at the heavy metal/grunge station Radio X. Radio X plays Welcome to the Jungle.
Chuck D of Public Enemy fame as "Forthright MC" on Playback FM and Motherfunking George Clinton himself as "The Funktopus" on Bounce FM. There are no Parliament/Funkadelic tracks in the game, but Bounce FM features a melody of many songs by the P-Funk collective, and sometimes, in the outro to "Rebel Without A Pause" Chuck D says "now Public Enemy is a group I have always been behind!" The meta here is sickening.
And Michael Bivins of New Edition and Bell Biv Devoe as the DJ of the new jack swing station CSR.
Los Santos, if not all of San Andreas, is getting re-imagined and revisited in the upcoming GTA V!
Just Los Santos, but it is huge. And there're plenty of Call Backs to this game: One of the radio stations is the HD equivalent of WCTR, the Epsilon Program led by Cris Formage. The gangs you'll come across are the Chamberlin Hills Grove Families, which is a branch of the Orange Grove Families. The Ballas, who had taken over the Grove Street cul-de-sac in the 21 years between the two games. The Los Santos Vagos and the Varrios Los Aztecas; the latter of which Cesar apparently moved on from because they're not so friendly story-wise anymore.
One of Lamar's missions you actually go to where CJ's house on the cul-de-sac would be. He doesn't live there anymore, most likely since GTA V takes place in a different era than GTA SA, but the Groove Street Families are referenced here and there. Turns out that they moved to greener pastures.
CJ can be heard being talked about in random street conversations in Grove Street and the surrounding areas, as well as some dialogue between Franklin and Lamar. He apparently has reached some kind of mythical status in his old neighborhood.