- Ascended Fanon: "Nyaako" is now the official name for that Cat Smile girl.
- Hey, It's That Voice!: Madarame is Viral in Otaku Mode. Also voices Madarame in Bleach as well.
- And Kasukabe is Kagome.
- Madarame's VA was Adult Link in Zelda: OOT. The funniest part is that Ogiue's VA played Navi.
- Kousaka is Takashi "Ten-chan" Ayanokouji (and its appearance is quite similar!).
- Domon Kasshu builds model kits in the same club with Guy Shishio, doujinshi fanatic and Gundam fan.
- Mikuru Asahina is now an American Japanophile.
- Never Trust a Title: Genshiken: Second Season is actually the third televised season, after Genshiken 2. The Japanese title actually literally translates as "Second Generation", which is more apt (dealing as it does with the "generation gap" between the old- and new guard of Otaku).
- Portmanteau Series Nickname: "Genshiken" and "Kujiun".