The 2012 movie:
- Actor Allusion: Clips of Christopher Lee from Horror of Dracula appear in the movie Mr. and Mrs. Frankenstein are watching on TV.
- All-Star Cast: ...Just look up.
- Cross Dressing Animal Vocal: Dee Bradley Baker as Persephone the female poodle.
- Dueling Movies: With ParaNorman.
- Hey, It's That Voice!: Frank Welker provides the voice of Sparky.
- Not only does Dee Bradley Baker voice Mr. Whiskers and Persephone the poodle but he also does Shelly, Were-Rat, and bat-kitty vampire hybrid.
- Jeff Bennett provides the voices of the sea monkeys.
- Rowley voices Victor's classmate Bob and...
...Berta the housekeeper is his mother.
- Toshiaki grows up to be Lance corporal Steven Mottola.
- Matty Newton's Edgar "E" Gore.
- Elsa van Helsing played the goth daughter to Mrs. Frankenstein in a Tim Burton film twenty four years before.
- Mr. Rzykruski played Bela Lugosi in a 1994 film by Tim Burton.
- Production Posse: No Johnny Depp or Helena Bonham-Carter, but Burton has worked with Ryder, Landau, Short, and O'Hara before.
- Reused Character Design: Sparky is a slightly chubbier version of The Dog from "Family Dog." Makes sense, as Burton was the character designer for both projects.
- Stock Footage: Susan and Ben Frankenstein are watching Horror of Dracula starring Christopher Lee as the count when Victor sneaks back into his house with Sparky's corpse.
- Voicing For Three: Catherine O'Hara does Mrs. Susan Frankenstein, "Weird Girl," and the gym teacher.
- Martin Short does Mr. Ben Frankenstein, Nassor and Mr. Burgermeister.