Actor Allusion: One episode featured a passing joke about Burt Reynolds, with one character mentioning his "broad shoulders and manly hands." Said character was voiced by Dom De Luise, who famously made several films with Reynolds.
All-Star Cast: As with most DreamWorks projects, this was one of its selling points. Aside from John Goodman, Carl Reiner and Cheryl Hines in the leads, nearly every guest star is at least an A-Minus-list celebrity.
Casting Gag: In "Donkey," Donkey (Eddie Murphy) has a stunt double who looks identical to him but has a wiry Camp Gay voice that sounds nothing like him. Said voice is Mark Mosley, who's second career is as an Eddie Murphy sound-alike.
This was the second of only two animated TV shows that was done by Imagi Studios, who moved on to feature films afterward. Then they did Astro Boy and that was the last anyone heard of them.
Along with Spirit: Stallion of the Cimarron, the show was the last project that DWA head Jeffrey Katzenberg had direct creative input in before he decided to resign to strictly producing.
And finally, this killed any chances of DreamWorks Animation doing prime-time television. All future DWA shows that air on television are either on Nickelodeon or Cartoon Network. They would eventually return to season-based series with All Hail King Julien.
Fake Nationality: British Jullian Holloway plays a fictionalized version of the German Siegfried Fischbacher. Holloway uses his normal voice as Col. Yum Yum in "Possession."
Genre-Killer: Along with Tripping the Rift and Game Over, this show set the bar exceptionally low for 3D computer animation being used for adult TV shows and there have been none since. 2D animation (with the occasional 3D effect) continues to reign supreme in TV animation for adults, while All-CGI Cartoons are limited to children's shows.
Keep Circulating the Tapes: There WAS a DVD release of this cartoon's only season, which included the series finale that was never aired (nor completed) in the United States. Despite that and winning an Annie, DWA immediately sent any trace of this show out to the middle of nowhere after it stopped airing and have refused to bring it up, so anyone who wants to see something from this show will need to track this DVD down on the internet.
Though it does crop on Netflix from time to time.
Missing Episode: Some broadcasts omit the "Panda episode", where Kate tries to matchmake her panda friend Foo Lin to a male panda, who falls for Kate instead.
The DVD has two episodes which never aired: "Siegfried and Roy: The Movie Fantasy Experience Movie" and "Stage Freight" (the pilot re-cut as an Origins Episode), as well as one episode that was only ever storyboarded.
Old Shame: DreamWorks Animation and show-runner/founder/CEO Jeffrey Katzenberg like to forget this show ever happened, to the point that their website lists Penguins of Madagascar as their first TV series!
Out of Order: The episode where Sarmoti first moves in with Larry and Kate was the second to last episode aired!
Schedule Slip: The show went on a weeks-long hiatus after "One Man's Meat Is Another Man's Girlfriend" aired due to low ratings. It was canceled a month later and the last three episodes were burned off on a single night in December.
Unfinished Episode: The episode "The Lost Tale" was not finished when the show got cancelled, and thus is included on the DVD in animatic form.
What Could Have Been: Another network was interested in picking up the show for a smaller budget and with some creative changes a year after it was canceled, but nothing came of it.