Creative Differences: Tamers owes its very existence to this. To recap, many of the staff including Konaka which were originally apart of the main staff for Digimon Adventure 02 were upset about the Executive Meddling and so they were about to quit the project even though they were under contract. So instead of letting them just leave and break contract, Bandai gave them and Konaka the next series, and then gave them the room to plan it out the way they wanted.
Depending on the Writer: Although at first glance the Ryo that appears in Tamers has a different personality from the one in the game, he was in fact written by the same person who wrote his character in the games, according to the main writer.
Word of God states that Impmon was originally conceived as the main character! When that was shot down, Impmon/Beelzemon was originally intended to be the Big Bad of the series, but was replaced by the D-Reaper and became The Atoner instead. This may explain why Impmon is portrayed in typical Big Bad fashion in the earlier promotional material.
Tamers was originally planned to be a direct sequel to Adventure continuity.
No Celebrities Were Harmed: Notably Pajiramon, whose English voice is a homage to Kate Mulgrew - Captain Janeway of Star Trek: Voyager. Mary Elizabeth McGlynn, who voiced Pajiramon and was this season's voice director, had guest starred in a Voyager episode.
Word of God: Arguably has the most All There in the Manual info out of any Digimon series due to Konaka's blog being publicly available and packed with information, and with an English translation to boot so that non-Japanese speakers can read.