- Dueling Games: With Shadowrun, primarilynote , the main difference between the two being Shadowrun's inclusion of fantasy elements (dragons, elves, magic, etc.). Purists stuck with the former, but the latter was more consistently popular thanks to cross-genre audience appeal. The release of Cyberpunk's much maligned 3rd Edition, combined with financial troubles at R. Talsorian, caused the game to disappear from shelves for several years, allowing Shadowrun to dominate the market, but with the announcement of the Cyberpunk 2077 video game adaptation and the upcoming release of new setting updates to go along with it (which disregard the 3rd Edition completely), Cyberpunk appears poised to make a comeback (altough the updates will not include rules or new editions, which doesn't help that much).
- Technology Marches On: Even with cyberspace, the computers of the future depicted in the game are really underpowered compared with Real Life ones of the same epoch and there's nothing, at least in the main rulebook, like a smartphone — mobile phones are of the dumb variety and more expensive than Real Life ones too. Those upcoming setting updates will very likely fix that.
- Unfortunately in space exploration, the Cyberpunk world has decades of advantage with Real Life one, with several space stations and even moonbases.